AustralieFrV1, Main, Exploration, bibRecord, 007794

In Vivo Parasitological Measures of Artemisinin Susceptibility

Identifieur interne : 007794 ( Main/Exploration ); précédent : 007793; suivant : 007795

In Vivo Parasitological Measures of Artemisinin Susceptibility

Auteurs : Kasia Stepniewska [Thaïlande] ; Elizabeth Ashley [Thaïlande, Royaume-Uni] ; Sue J. Lees [Thaïlande] ; Nicholas Anstey [Australie] ; Karen I. Barnes [Afrique du Sud] ; Tran Quang Binh [Viêt Nam] ; Umberto D'Alessandro [Belgique] ; Nicholas P. J. Day [Thaïlande, Royaume-Uni] ; Peter J. De Vries [Pays-Bas] ; Grant Dorsey [États-Unis, Burkina Faso, Ouganda] ; Jean-Paul Guthmann [France] ; Mayfong Mayxay [Laos] ; Paul N. Newton [Laos] ; Piero Olliaro [Royaume-Uni] ; Lyda Osorio [Colombie] ; Ric N. Price [Australie, Royaume-Uni] ; Mark Rowland [Royaume-Uni] ; Frank Smithuis [Birmanie] ; Walter R. J. Taylor [Suisse] ; François Nosten [Thaïlande, Royaume-Uni] ; Nicholas J. White [Thaïlande, Royaume-Uni]

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2010.

RBID : Pascal:10-0117518

Descripteurs français

Pascal (Inist)
- Sensibilité, Infection, Artémisinine, Antiparasitaire, Antipaludique.

English descriptors

KwdEn :
- Antimalarial, Artemisinin, Infection, Parasiticide, Sensitivity.

Abstract

Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n = 14,539), moderate (n = 2077), and high (n = 2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/μL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n+60)/24.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291277

Affiliations:

Afrique du Sud, Australie, Belgique, Birmanie, Burkina Faso, Colombie, France, Laos, Ouganda, Pays-Bas, Royaume-Uni, Suisse, Thaïlande, Viêt Nam, États-Unis
Angleterre, Californie, Grand Londres, Hollande-Septentrionale, Oxfordshire, Île-de-France
Amsterdam, Londres, Oxford, Paris, San Francisco
Université d'Oxford

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">In Vivo Parasitological Measures of Artemisinin Susceptibility</title>
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</inist:fA14>
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</author>
<author><name sortKey="Day, Nicholas P J" sort="Day, Nicholas P J" uniqKey="Day N" first="Nicholas P. J." last="Day">Nicholas P. J. Day</name>
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<sZ>2 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
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<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarial</term>
<term>Artemisinin</term>
<term>Infection</term>
<term>Parasiticide</term>
<term>Sensitivity</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Sensibilité</term>
<term>Infection</term>
<term>Artémisinine</term>
<term>Antiparasitaire</term>
<term>Antipaludique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n = 14,539), moderate (n = 2077), and high (n = 2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/μL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n+60)/24.</div>
</front>
</TEI>
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<li>Australie</li>
<li>Belgique</li>
<li>Birmanie</li>
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<li>Colombie</li>
<li>France</li>
<li>Laos</li>
<li>Ouganda</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
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<li>Viêt Nam</li>
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<li>Oxford</li>
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Serveur d'exploration sur les relations entre la France et l'Australie

In Vivo Parasitological Measures of Artemisinin Susceptibility

In Vivo Parasitological Measures of Artemisinin Susceptibility

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	Serveur d'exploration sur les relations entre la France et l'Australie
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